Optical Imaging Laboratory

 

Department of Electrical and Computer Engineering

University of Michigan-Shanghai Jiao Tong University Joint Institute

Shanghai Jiao Tong University

Home Research Members Publications Courses Links
 
Current Research Directions:
 
 
 
 
 

We develop miniature probes and resolution-enhancement algorithms for photoacoustic imaging, and explore its biomedical and industrial applications. Photoacoustic imaging is able to visualize optical absorption contrast, which renders the imaging technology powerful for various applications. By utilizing low ultrasonic scattering, photoacoustic imaging enables deeper penetration in biological tissues at high spatial resolutions compared with existing optical imaging technologies. On the other hand, compared with ultrasound imaging, photoacoustic imaging can reveal rich information associated with absorption contrast. Besides photoacoustic imaging, we also develop novel optical imaging systems such as time-gated fluorescence imaging, and explore applications in cell imaging and early detection of cancer. Please visit each Research Direction to see the specific details.

 
 
Media Coverage & Journal Cover:
 
[Journal Cover] February, 2020 ACS Applied Energy Materials: Photoacoustic imaging of lithium metal batteries
 

A novel photoacoustic imaging technology is explored to potentially reveal lithium dendrite growth process, a critical issue leading to short circuit and even explosion of lithium metal batteries. The results suggest that photoacoustic imaging can be a powerful tool to provide the insight into the formation of dendrites through high-resolution, high-contrast, and three-dimensional visualization of lithium protrusions. The work demonstrated herein may open up new avenues for the investigation of the safety hazards of lithium metal batteries.

https://pubs.acs.org/toc/aaemcq/3/2

[Publication]

 
[Media Coverage] July, 2019 X-MOL: High performance optomechanical time-gated fluorescence imaging based on long-lived silicon quantum dot nanoparticle probes
 

[in Chinese] >>link

 
[Media Coverage] March, 2019 Biophotonics.World: Miniature Probe for Photoacoustic Imaging
 

A research team at Shanghai Jiao Tong University, China has developed a miniature probe for photoacoustic microscopy (PAM). The probe, as an embodiment of PAM, is small and light, which may facilitate various potential clinical applications in future. Imaging of mouse ear in vivo using the probe has been demonstrated in the article published in Journal of Biophotonics in 2018...>>link

 
[Media Coverage] December, 2018 Advances in Engineering News: Miniaturization of optical- and acoustic-resolution photoacoustic microscopy scan head for scalable resolution and depth in endoscopy
 

Recently, a team of researchers led by Professor Sung-Liang Chen from the University of Michigan-Shanghai Jiao Tong University Joint Institute developed a miniature probe capable of both OR- and AR-PAM. They utilized a gradient-index-lens fiber and a multimode fiber to deliver light for OR and AR illumination, respectively. They aspired to achieve scalable resolution and depth in endoscopy using their novel miniature probe and high-quality in vivo images comparable to those acquired by the current bulky counterparts...>>link

 
[Journal Cover] December, 2018 Journal of Biophotonics Inside Front Cover: Miniature probe for all‐optical double gradient‐index lenses photoacoustic microscopy
 

Optical‐resolution photoacoustic microscopy and endoscopy are powerful tools for medical imaging. However, implementation of the imaging heads or miniature imaging probes with high resolution and long working distance has been technically challenging. The novel design of using double gradient‐index lenses for light focusing and a fiber Fabry‐Perot ultrasound sensor for sound detection provides a simple approach to implement such a miniature imaging probe.

https://www.onlinelibrary.wiley.com/doi/10.1002/jbio.201870171

[Publication]

 
 
Funding Sources
[Industry funding] Anyang Youchuang Industrial Co., Ltd. (安阳优创实业有限责任公司) "Intelligent control and identification system of cross-rack safety and quality" 220,000 RMB, PI
[Industry funding] Luoyang Longyu Group Co., Ltd. (洛阳龙羽集团有限公司) "Automatic intelligent inspection APP for the offset of the center of anchor bolts to that of the main column in the same group" 150,000 RMB, PI
NSFC, 82130057, "Diagnosis of carotid artery plaque based on multi-scale photoacoustic molecular imaging and artificial intelligence" 2,900,000 RMB, Co-PI, share 1,450,000 RMB (PI: Rong Wu (Shanghai General Hospital))
DMCT, seed fund, "Three-dimensional photoacoustic imaging of subchondral microvessels in mouse knee osteoarthritis model" and "Study on microcirculation changes of myogenic temporomandibular joint disorder based on photoacoustic microscopy," 200,000 RMB, Co-PI, share 100,000 RMB (PI: Chenglei Liu (Shanghai Ninth People's Hospital), PI: Lili Xu (Shanghai Ninth People's Hospital))
SJTU, Interdisciplinary medicine-engineering research fund, "Study of quantitative monitoring of microcirculation status for early recognition of sepsis patients using photoacoustic microscopy," 300,000 RMB, Co-PI, share 200,000 RMB by contract (PI: Yuan Gao and Yuxiao Deng (Renji Hospital))
 
Past Funding
NSFC, 61775134, "Focusing-free photoacoustic endomicroscopy based on a miniature fiber photoacoustic imaging probe and a mirrored synthetic aperture" 660,000 RMB (overhead excluded), PI
[Industry funding] Palmary Technology Ltd. (北京帕莫瑞科技有限公司) "Development of algorithms for continuous online monitoring of two-dimensional temperature fields based on acoustic waves" 50,000 RMB, PI
SJTU, 15X190020085, "Study of the change of microcirculation by photoacoustic imaging during the treatment of sepsis by mesenchymal stem cells" 210,000 RMB, Co-PI, share 70,000 RMB (PI: Yuxiao Deng (Renji Hospital))
SJTU, State Key Lab, "Non-contact all-optical photoacoustic endomicroscopy" 200,000 RMB, PI
STCSM, 15140901400, "Development of dorsal skin fold window chamber in nude mice and its application in tumor photoacoustic imaging" 250,000 RMB, Co-PI, share 50,000 RMB (PI: Lixin Jiang (6th People's Hospital))
MOST (Youth 863 Program), 2015AA020944, "Optical coherence tomography and photoacoustic dual-modality endoscopic imaging for the diagnosis of atherosclerosis" 1,180,000 RMB, Co-PI, share 370,000 RMB (PI: Jigang Wu, other Co-PIs: Tian Yang, Lixin Jiang (6th People's Hospital))
NSFC, 61405112, "Large depth-of-field photoacoustic microscopy based on optical millimeter-ring resonators" 260,000 RMB, PI
STCSM, Shanghai Pujiang Talent Program 2014, 14PJ1404400, "All-optical integrated optical- and acoustic-resolution photoacoustic microscopy" 200,000 RMB, PI

[Industry funding] Covidien Master Product Innovation, "Optical-resolution photoacoustic endoscopic probe" 100,000 RMB, PI

 

Copyright (C) 2022 UM-SJTU Joint Institute